The adventures of a spirited boy growing up in a Mississippi River town in the nineteenth century, as he tries a new method for curing warts, witnesses a murder, runs away to an island and pretends to be a pirate, watches his own funeral, and falls for the new girl in the neighborhood.

1932, Minnesota. The Lincoln School is a pitiless place where hundreds of Native American children, forcibly separated from their parents, are sent to be educated. It is also home to an orphan named Odie O'Banion, a lively boy whose exploits earn him the superintendent's wrath. Forced to flee, he and his brother Albert, their best friend Mose, and a little girl named Emmy steal away in a canoe, heading for the mighty Mississippi and a place to call...