The VKs return to the Isle of the Lost to recruit a new batch of villainous offspring to join them at Auradon Prep. When a barrier breach jeopardizes the safety of Auradon during their departure off the Isle, Mal resolves to permanently close the barrier, fearing that nemeses Uma and Hades will wreak vengeance on the kingdom. Despite her decision, an unfathomable dark force threatens the people of Auradon, and it is up to Mal and the VKs to save everyone...

Despite his family's generations-old ban on music, Miguel dreams of becoming an accomplished musician like his idol, Ernesto de la Cruz. Desperate to prove his talent, Miguel finds himself in the stunning and colorful Land of the Dead following a mysterious chain of events. Along the way, he meets charming trickster Hector, and together, they set off on an extraordinary journey to unlock the real story behind Miguel's family history.