"Hidden in the depths of eighteenth-century London, a secret apothecary shop caters to an unusual kind of clientele. Women across the city whisper of a mysterious figure named Nella who sells well-disguised poisons to use against the oppressive men in their lives. But the apothecary's fate is jeopardized when her newest patron, a precocious twelve-year-old, makes a fatal mistake, sparking a string of consequences that echo through the centuries. Meanwhile...

In 1665 London, fourteen-year-old Christopher Rowe, apprentice to an apothecary, and his best friend, Tom, try to uncover the truth behind a mysterious cult, following a trail of puzzles, codes, pranks, and danger toward an unearthly secret with the power to tear the world apart.

Arriving in the small prairie town of Buffalo Valley in North Dakota to visit an old family friend while his reluctant fiancee makes up her mind, Vaughn Kyle encounters Carrie Hendrickson and soon everything he once thought he wanted is called into question.